IAP (inhibitor of apoptosis protein) is an evolutionarily-conserved inhibitory factor of apoptosis. IAP directly binds to caspase which plays the central role in operation of apoptosis and inhibits it. Human XIAP (X-chromosome-linked inhibitor of apoptosis protein) is known as one of the IAP family and binds to caspase-3, 7, and 9 directly and inhibits their functions. XIAP has three BIR (baculovirus IAP repeat) domains. It is confirmed that BIR2 domain binds to caspase-3 and 7, and BIR3 domain binds to caspase-9. Also it has known that the RING finger domain has a ubiquitin ligase activity and is associated with ubiquitination of caspase. For research use only, not for use in diagnostic procedures.
- application:
- WB
- Catalog number:
- 28059
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Synthetic peptide of a part of Human XIAP (aa244-263: VSSDRNFPNSTNLPRNPSMA)
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- purification:
- Purified with antigen peptide
- size:
- 50 µg
- specificity:
- Cross-reacts with mouse
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C.
- Species:
- Human
- Host:
- Rabbit
